Research synthesis

The Centre has worked on a variety of systematic reviews, some of which have become part of national and international guidelines. This work is led by Peter Lepping.

Using the technology of systematic reviews, we have developed a novel method to test the clinical relevance of research findings. To achieve this we used translations of psychometric symptom (such as the Hamilton Depression Rating Scale or Positive And Negative Symptom Scale) into clinical scores such as the Clinical Global Impressions scale. This allows re-analysis of data to facilitate a more meaningful appraisal of a treatment’s effect on patients’ wellbeing, for example, cognitive-behavioural therapy (see here). We have worked with renowned researchers such as Prof Richard Whittington in Liverpool and Prof Stefan Leucht in Munich as well as other national and international colleagues to test the clinical relevance of the data on the efficacy of a variety of treatments in psychiatry.

We continue to publish conventional systematic reviews, including some on neglected conditions such as alcoholic hallucinosis.

Lepping P, Whittington R, Sambhi RS, Lane S, Poole R, Leucht S, Cuijpers P, McCabe R, Waheed W (2017) Clinical relevance of findings in trials of CBT for depression. Eur Psychiatry. 45: 207-211

Masood B, Lepping P, Romanov P, Poole R (2018) Treatment of alcohol induced psychotic disorder (alcoholic hallucinosis) – a systematic review. Alcohol & Alcoholism 53, 3, 259–267

Back to homepage